Adrenal insufficiency Ketoconazole is known to cause adrenal insufficiency, and this fluconazole also although rarely seen be applicable to fluconazole. Adrenal insufficiency relating to concomitant treatment with Prednisone is described in section 4. Fluconazole capsule has been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions.

In cases of fluconazole associated hepatotoxicity, no obvious relationship to total daily dose, fluconazole usp 50 mg, duration of therapy, fluconazole usp 50 mg, fluconazole or age of patient has been observed. Fluconazole hepatotoxicity has usually been reversible on discontinuation of usp. Patients who develop abnormal usp function tests during fluconazole therapy must be monitored closely for the development of more serious hepatic injury. dramamine customer reviews

fluconazole 150 mg - oral, Diflucan

The patient should be informed of suggestive symptoms of serious hepatic effect important usp, anorexia, fluconazole usp 50 mg, persistent nausea, vomiting and jaundice. Treatment of fluconazole should be immediately discontinued and the patient should consult a physician. Cardiovascular system Some azoles, including fluconazole, have been associated with prolongation of the QT interval on the electrocardiogram. The QT prolongation caused by other medicinal products such as amiodarone may be amplified via fluconazole inhibition of cytochrome P CYP 3A4.

During post-marketing surveillance, there have been very rare cases of QT prolongation and torsades de pointes in patients taking Fluconazole capsule. These reports included seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities and concomitant treatment that may have been contributory.

Patients with hypokalemia and advanced cardiac failure are at an increased risk for the occurrence of life threatening ventricular arrhythmias and torsades de pointes.

Fluconazole capsule should be administered with caution to patients with these potentially proarrhythmic conditions. Coadministration of usp medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P CYP 3A4 are contraindicated see sections 4.

The concomitant use of fluconazole and halofantrine is therefore not recommended see section 4. Caution must be exercised if the concomitant use of fluconazole and amiodarone is necessary see section 4.

Dermatological reactions Patients have rarely developed exfoliative cutaneous reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, during treatment with fluconazole. AIDS patients are more prone to the development of severe cutaneous reactions to many medicinal products. If a rash, fluconazole usp 50 mg, which is considered attributable to fluconazole, develops in a patient treated for a superficial fungal infection, further therapy with this medicinal product should be discontinued.

Hypersensitivity In rare cases anaphylaxis has been reported see section 4. Fluconazole is also a strong inhibitor of CYP2C Terfenadine The coadministration of fluconazole at doses lower than mg per day with terfenadine should be carefully monitored see sections 4. Excipients Capsules contain lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

There have been reports of cardiac events including Torsades de Pointes in patients to whom fluconazole and cisapride were coadministered. A controlled study found that concomitant fluconazole mg once daily and cisapride 20 mg four times a day yielded a significant increase in cisapride plasma levels and prolongation of QTc interval, fluconazole usp 50 mg.

Concomitant treatment with fluconazole and cisapride is contraindicated see section 4. Experiences with cytotec of the occurrence usp serious cardiac dysrhythmias secondary to prolongation of the QTc interval in patients receiving azole antifungals in conjunction with terfenadine, interaction studies have been performed.

One study at a mg daily dose of fluconazole failed to demonstrate a prolongation in QTc interval. Another study at a mg and mg daily dose of fluconazole demonstrated that fluconazole taken in doses of mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly.

The combined use of fluconazole at doses of mg or greater with terfenadine is contraindicated see section 4. The coadministration fluconazole fluconazole at doses lower than mg per day with terfenadine should be carefully monitored. Concomitant administration fluconazole fluconazole with astemizole may decrease the clearance of astemizole.

Resulting increased plasma concentrations of astemizole can lead to QT prolongation and rare occurrences of torsades de pointes. Coadministration of fluconazole and astemizole is contraindicated see section 4. Although not studied in vitro or in vivo, concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism.

Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsades de pointes. Coadministration of fluconazole and pimozide is contraindicated see section 4. Although not studied in vitro or in vivo, concomitant administration of fluconazole with quinidine may result in inhibition of quinidine metabolism.

Use of quinidine has been associated with QT prolongation and rare occurrences of torsades de pointes, fluconazole usp 50 mg.

Coadministration of fluconazole and quinidine is contraindicated see section 4. Concomitant use of fluconazole and erythromycin has the potential to increase the risk of cardiotoxicity prolonged QT interval, Torsades de Pointes usp consequently sudden heart death.

Coadministration of fluconazole and erythromycin is contraindicated see section 4. Concomitant use of the following other medicinal products cannot be recommended: Fluconazole can increase halofantrine plasma concentration due to an inhibitory effect on CYP3A4.

Concomitant use of fluconazole and halofantrine has the potential to increase the risk of cardiotoxicity prolonged Fluconazole interval, torsades de pointes and consequently sudden heart death. This combination usp be avoided see section 4.

Concomitant use that should be used with caution: Concomitant administration of fluconazole with amiodarone may increase QT prolongation.

Therefore, caution should be taken when both drugs are combined, fluconazole usp 50 mg, notably with high dose fluconazole mg.

Thus, multiple dose use of Fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive, fluconazole usp 50 mg. Pimozide Although not studied in vitro or in vivo, concomitant administration of Fluconazole with pimozide may result in inhibition of pimozide metabolism.

Increased pimozide plasma concentrations can usp to QT prolongation and fluconazole occurrences of torsade de pointes. Coadministration of Fluconazole and pimozide is contraindicated. Quinidine Although not studied in vitro or in vivo, concomitant administration of Fluconazole with quinidine may result in inhibition of quinidine metabolism. Use of quinidine has been associated with QT prolongation and rare occurrences of torsade de pointes.

Coadministration of Fluconazole and quinidine is contraindicated. An effect of this magnitude should not necessitate a change in the Fluconazole dose regimen in subjects receiving concomitant diuretics. Dosage adjustment of alfentanil may be necessary.

Amiodarone Concomitant administration of Fluconazole with amiodarone may increase QT prolongation. Caution must be exercised if the concomitant use of Fluconazole and amiodarone is necessary, fluconazole usp 50 mg, notably with high dose Usp mg. Amitriptyline, nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline, fluconazole usp 50 mg. Amphotericin B Concurrent administration of Fluconazole and amphotericin B in infected normal and immunosuppressed mice showed the following results: The clinical significance of results obtained in these studies is unknown.

Azithromycin An open-label, usp, three-way crossover study fluconazole 18 healthy subjects assessed the effect of a single mg oral dose of azithromycin on the pharmacokinetics of a fluconazole mg oral dose of Fluconazole as well as the effects of Fluconazole on the pharmacokinetics of azithromycin.

There was no significant pharmacokinetic interaction between Fluconazole and azithromycin. There is a risk of developing carbamazepine toxicity.

Calcium channel blockers Certain calcium channel antagonists nifedipine, isradipine, amlodipine, verapamil, and felodipine are metabolized by CYP3A4. Fluconazole has the potential to increase the systemic exposure of the calcium channel antagonists. Frequent monitoring for adverse events is recommended. Fluconazole of the celecoxib dose may be necessary when combined with Fluconazole. Cyclophosphamide Combination therapy with cyclophosphamide and Fluconazole results in an increase in serum bilirubin and serum creatinine.

The combination may be used while taking increased consideration to the risk of increased serum bilirubin and serum creatinine. Fentanyl One fatal case of possible fentanyl-Fluconazole interaction was reported.

The author judged that the patient died from fentanyl intoxication. Furthermore, in a randomized crossover study with 12 healthy volunteers, fluconazole usp 50 mg, it was shown that Fluconazole delayed the elimination of fentanyl significantly. Elevated fentanyl concentration may lead to respiratory depression. Halofantrine Fluconazole can increase halofantrine xanax valium codeine concentration due to an inhibitory effect on CYP3A4.

If concomitant therapy is necessary, fluconazole usp 50 mg, the patient should be observed for symptoms of myopathy and rhabdomyolysis and creatinine kinase should be monitored. Losartan Fluconazole inhibits the metabolism of losartan to its active metabolite E 74 which is responsible for most of the angiotensin II-receptor antagonism which occurs during treatment with losartan.

Patients should have their blood pressure monitored continuously, fluconazole usp 50 mg. Methadone Fluconazole may enhance the serum concentration of methadone. Dosage usp of methadone may be necessary. Although not specifically studied, Fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs Usp purchase accutane with are metabolized by CYP2C9 e.

Prednisone There was a case report that a liver-transplanted patient treated with prednisone developed acute adrenal cortex insufficiency when a 3 month therapy with Fluconazole was discontinued. The discontinuation of Fluconazole presumably caused an enhanced CYP3A4 activity which led to increased fluconazole of prednisone. Patients on long-term treatment with Fluconazole and prednisone should be carefully monitored for adrenal cortex insufficiency when Fluconazole fluconazole discontinued.

Fluconazole

Dosage adjustment of gabapentin 100mg capsules nhs may be necessary. Sirolimus Fluconazole increases plasma concentrations of sirolimus presumably by inhibiting the metabolism of sirolimus via CYP3A4 and P-glycoprotein. Vinca alkaloids Although not studied, Fluconazole may increase the plasma levels of the vinca alkaloids e.

Vitamin A Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid an acid form of vitamin A and Fluconazole, central nervous system Fluconazole related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of Fluconazole treatment.

This combination may be used but the incidence of CNS related undesirable effects should be borne in mind. Patients receiving this combination should be monitored for the development of zidovudine-related adverse reactions. Dosage reduction of zidovudine may be considered.

Carcinogenesis, Mutagenesis, and Impairment of Fertility Fluconazole showed no evidence of carcinogenic potential in mice and rats treated orally usp 24 months fluconazole doses of 2. Monitoring for adverse events and toxicity related to voriconazole is recommended; especially, if voriconazole is started within 24 h after the last dose of fluconazole.

Fluconazole may increase the serum usp of orally administered tacrolimus up to 5 times due to inhibition of tacrolimus metabolism through CYP3A4 in the intestines. No significant pharmacokinetic changes have been observed when tacrolimus is given intravenously. Increased tacrolimus levels have been associated with nephrotoxicity. Dosage of orally administered tacrolimus should be decreased depending on tacrolimus concentration.

Following oral administration of midazolam, fluconazole usp 50 mg, fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects.

Fluconazole Tablets की पूरी जानकारी हिंदी में

This effect on midazolam appears to be more pronounced following oral administration of fluconazole than with fluconazole administered intravenously. If short-acting benzodiazepines, fluconazole are metabolized by the cytochrome P system, are concomitantly administered with fluconazole, consideration should be given to decreasing the benzodiazepine dosage, and the patients should be appropriately monitored.

Systemic exposure to tofacitinib is increased when tofacitinib is coadministered with fluconazole, a combined moderate CYP3A4 and potent CYP2C19 inhibitor. Reduce the dose of tofacitinib when given concomitantly with fluconazole i. Dosage adjustments of triazolam may be necessary.

Two pharmacokinetic studies with a combined oral contraceptive have been performed using multiple doses of fluconazole.

Thus, multiple-dose usp of fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive. Although not studied in vitro or in vivo, concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism. Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsade de pointes, fluconazole usp 50 mg. Coadministration of fluconazole and pimozide is contraindicated.

Although not studied in vitro or in vivo, concomitant administration of fluconazole with quinidine may result in inhibition of quinidine metabolism, fluconazole usp 50 mg. Use of quinidine has been associated with QT prolongation and rare occurrences of torsade fluconazole pointes.

Coadministration of fluconazole and apap codeine anti inflammatory is contraindicated, fluconazole usp 50 mg.

An effect of this magnitude should not necessitate a change in the fluconazole dose regimen in subjects receiving concomitant diuretics. Dosage adjustment of alfentanil may be necessary. Concomitant administration of fluconazole with amiodarone may increase QT prolongation. Caution must be exercised usp the concomitant use of fluconazole and amiodarone is necessary, notably with high-dose fluconazole mg.

Fluconazole usp the effect of amitriptyline and nortriptyline. Concurrent administration of fluconazole and amphotericin B in infected normal and immunosuppressed mice showed the following results: The clinical significance of results obtained in these studies fluconazole unknown, fluconazole usp 50 mg. An open-label, fluconazole usp 50 mg, randomized, three-way crossover study in 18 healthy subjects assessed the effect of a single mg oral dose of azithromycin on the pharmacokinetics of a single mg oral dose of fluconazole as well as the effects of fluconazole on the pharmacokinetics of azithromycin, fluconazole usp 50 mg.

There was no significant pharmacokinetic interaction between fluconazole and azithromycin. Fluconazole is a risk of developing carbamazepine toxicity.

Fluconazole has the potential fluconazole increase the systemic exposure of the calcium channel antagonists. Frequent monitoring for adverse events is recommended.

Half of the celecoxib usp may be necessary when combined with fluconazole. Combination therapy with cyclophosphamide and fluconazole results in an increase in serum bilirubin and serum creatinine.

The combination may be used while taking increased consideration to the risk of increased serum bilirubin and serum creatinine. Usp fatal case of possible fentanyl-fluconazole interaction was reported.

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