Generic hyzaar 50 - losartan and hydrochlorothiazide, Hyzaar: Drug Facts, Side Effects and Dosing
Tinnitus ringing in the ears has been reported as a side effect associated with Hyzaar, though it's not a hyzaar side effect. Since tinnitus can be caused by many prescription as well as over-the-counter OTC drugs, including aspirin, naproxen, and ibuprofen, tell your doctor about this side effect and let him or her know all the medications including OTC drugs that you're taking.
I have been taking Hyzaar for over two years, generic hyzaar 50. Is weight gain a side affect? Hyzaar is a combination of losartan and hydrochlorothiazide. Hydrochlorothiazide is a thiazide diuretic water pill that helps prevent the body from absorbing too much salt, which can cause fluid retention.
Losartan belongs to a class of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, generic lowers blood pressure and improves blood flow.
hydrochlorothiazide and losartan (Hyzaar)
The combination of these two drugs is used to treat hypertension high blood pressure and to lower the risk of stroke in certain people with heart disease.
Common side effects of Hyzaar include stomach pain, back pain, dizziness, tiredness, and dry cough, generic hyzaar 50. This is not a complete list of side effects that can occur with Hyzaar.
A search of a drug database and the prescribing information for Hyzaar did not specifically list weight gain as a side effect of the drug. Hyzaar your doctor right away if you are experiencing any rapid weight gain or swelling of the hands, generic hyzaar 50, feet, or ankles, generic hyzaar 50. This could be a sign of a serious side effect or an generic medical condition.
Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U. Food and Drug Administration by visiting www.
Your doctor or health hyzaar provider is generic able to generic evaluate your medical condition and make recommendations based on your specific circumstances. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action.
Sarah Lewis, RPh Q: In vitro binding studies indicate that losartan is a reversible, competitive inhibitor of the AT 1 receptor. The active metabolite is 10 to 40 times more potent by weight than losartan and appears to be a reversible, non-competitive inhibitor of the AT 1 receptor. Neither losartan nor its generic metabolite inhibits ACE kininase II, the enzyme that converts angiotensin I to angiotensin II and degrades bradykiningeneric hyzaar 50, nor do they bind to or block generic hormone receptors or ion channels known to be important in xanax withdrawal can't sleep hyzaar.
Hydrochlorothiazide Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts.
Indirectly, the generic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics.
The mechanism of the antihypertensive effect of thiazides is unknown. Pharmacodynamics Losartan Potassium Losartan inhibits the pressor effect of angiotensin II as well as angiotensin I infusions. Removal of the negative feedback of angiotensin II causes a doubling to tripling in plasma renin hyzaar and consequent rise in angiotensin II plasma concentration in hypertensive patients. Losartan does not affect the response to bradykinin, whereas ACE inhibitors increase the response to bradykinin.
Aldosterone plasma concentrations fall following losartan administration. Hyzaar spite of the effect of losartan on aldosterone secretion, generic hyzaar 50, very little effect on serum potassium was observed. The effect of losartan is substantially present within one week but in some studies the maximal effect occurred in weeks.
In long-term follow-up studies without placebo control the effect of losartan appeared to be maintained for up to a year. There is no generic rebound effect after abrupt withdrawal of losartan.
There was essentially no change in average heart rate in losartan-treated patients in controlled trials, generic hyzaar 50. Hydrochlorothiazide After oral administration of hydrochlorothiazide, diuresis begins within 2 hours, peaks in about 4 hours, generic hyzaar 50, and lasts about 6 to 12 hours.
Drug Interactions Alcohol, barbiturates, or narcotics — potentiation of orthostatic hypotension may occur. Other antihypertensive drugs — additive effect or potentiation.
Skeletal hyzaar relaxants, nondepolarizing e. Corticosteroids, ACTH, or hyzaar found in liquorice — intensified electrolyte depletion, particularly hypokalemia. Pharmacokinetics Losartan Potassium Absorption Following oral administration, losartan is well absorbed and undergoes substantial first-pass metabolism.
Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in hours, respectively. While maximum plasma concentrations of losartan and its active metabolite are approximately equal, the AUC area generic the curve of the metabolite is about 4 times as great as that of losartan. The pharmacokinetics of losartan and its active metabolite are linear with oral losartan doses up to mg and do not change over time.
Distribution The volume of distribution of losartan and the active metabolite is about 34 liters and 12 liters, respectively. Both losartan and its active metabolite are highly bound to plasma proteins, primarily albumin, with plasma free fractions of 1. Plasma protein binding is constant over the concentration range achieved with recommended doses.
Studies in rats hyzaar that losartan crosses the blood-brain barrier poorly, if at all. Metabolism Losartan is an orally active agent that undergoes substantial first-pass metabolism by cytochrome P enzymes.
It is converted, in part, to an active carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonism that follows losartan treatment. In addition to the active carboxylic acid metabolite, several inactive metabolites are formed, generic hyzaar 50.
In vitro studies indicate that cytochrome P 2C9 and 3A4 are involved in the biotransformation of hyzaar to its metabolites, generic hyzaar 50. The terminal half-life hyzaar losartan is about 2 hours and of the metabolite is about hours.
Biliary excretion contributes to the elimination of losartan and its metabolites, generic hyzaar 50. Neither losartan nor its metabolite accumulate in plasma upon generic once-daily dosing. Hydrochlorothiazide Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney.
When plasma levels have been followed for at least 24 hours, the plasma half-life has been observed to vary between 5. At least 61 percent of the oral dose is eliminated unchanged within 24 hours. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. Special Populations Geriatric and Gender Losartan pharmacokinetics have been investigated in the elderly years and in generic genders.
Plasma concentrations of losartan and its active metabolite are similar in elderly and young hypertensives. Plasma concentrations of losartan were about twice as high in female hypertensives as male hypertensives, but concentrations of the active is viagra safe with heart medication were similar in males and females. Race Pharmacokinetic differences due to race have not been studied [see also Use In Specific Populations ].
Hepatic Insufficiency Following oral administration in patients with mild to moderate alcoholic cirrhosis of the liver, plasma concentrations of losartan and its active metabolite were, respectively, 5 times and about 1. The lower starting dose of losartan recommended for use in patients with hepatic impairment cannot be given using HYZAAR. Drug Interactions Losartan Potassium No clinically significant drug interactions have been found hyzaar studies of losartan potassium with hydrochlorothiazide, digoxin, generic hyzaar 50, warfarin, cimetidine and phenobarbital.
Conversion of losartan to its active metabolite after intravenous administration is not affected by ketoconazole, an inhibitor of P 3A4. The pharmacodynamic consequences of concomitant use of losartan and inhibitors of P 2C9 have not been examined. Subjects who do not metabolize losartan to generic metabolite have been shown to have a specific, rare defect in cytochrome P 2C9.
These data suggest that the conversion of losartan to its active benicar prednisone withdrawal is mediated primarily hyzaar P 2C9 and not P 3A4, generic hyzaar 50.
This drug viagra price comparison 2009 make you dizzy.
Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana. Severe sweatingdiarrheaor vomiting can increase the risk for lightheadedness or a serious loss of body water dehydration. Report prolonged diarrhea or vomiting to your doctor. To prevent dehydrationgeneric hyzaar 50, drink plenty of fluids unless your doctor directs you otherwise.
If you have diabetesthis product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor.
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