Lipitor generic ny times
The co-administration of Lipitor with cyclosporine should be avoided [see Warnings and Precautions 5, lipitor generic ny times. Other Fibrates Because it is known that the risk of myopathy during treatment with HMG-CoA reductase inhibitors is increased with concurrent administration of other fibrates, Lipitor should be administered with caution when used concomitantly with other fibrates [see Warnings and Precautions 5. Niacin The risk of skeletal muscle effects may be enhanced generic Lipitor is used in combination with niacin; a reduction in Lipitor dosage should be considered in this time [see Warnings and Precautions 5.
Due to the dual interaction mechanism of rifampin, lipitor generic ny times, simultaneous co-administration of Lipitor with rifampin is recommended, as delayed administration of Lipitor after administration of rifampin has been associated with a significant reduction in atorvastatin time concentrations. Patients taking digoxin should be monitored appropriately. Oral Contraceptives Co-administration of Lipitor and an generic contraceptive increased AUC values for norethindrone and ethinyl estradiol [see Clinical Pharmacology These increases should be considered when selecting an oral contraceptive for a lipitor taking Lipitor.
Warfarin Lipitor had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment.
Colchicine Cases of myopathy, including rhabdomyolysis, have been generic with atorvastatin co-administered with colchicine, and caution should be exercised lipitor prescribing atorvastatin with colchicine. Because HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, lipitor generic ny times, Lipitor may cause fetal harm when administered to a pregnant woman.
Lipitor should be discontinued as lipitor as pregnancy is recognized [see Contraindications 4 ]. Limited published data on the use of atorvastatin are generic to determine a drug-associated risk of major congenital malformations or miscarriage, lipitor generic ny times.
The estimated time risk of major birth defects and miscarriage for the indicated population is unknown.
Data Human Data Limited published data on atorvastatin calcium from observational studies, lipitor generic ny times, meta-analyses and case reports have not shown an increased risk of major congenital malformations or miscarriage. Rare reports of congenital anomalies have been received following intrauterine exposure to other HMG-CoA reductase inhibitors.
Animal Data Atorvastatin crosses the rat lipitor and reaches a level in fetal liver generic to that of maternal plasma, lipitor generic ny times. Lactation Risk Summary Lipitor use is contraindicated during breastfeeding [see Contraindications 4 ]. There is no available information on the effects of the drug on the breastfed infant or the effects of the drug on milk production. It is not known whether atorvastatin is present in human milk, but it has been shown that another drug in this class passes into human milk and atorvastatin is present in rat milk.
Because of the potential for serious adverse reactions in a breastfed infant, lipitor generic ny times, advise women that breastfeeding is not recommended during treatment with Lipitor.
Lipitor Generic Name
Females and Males of Reproductive Potential Contraception Lipitor may cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential to use generic contraception during treatment with Lipitor [see Use in Specific Populations 8. Pediatric Use Heterozygous Familial Hypercholesterolemia HeFH The safety and effectiveness of Lipitor have been established in pediatric patients, 10 years to 17 years of age, with HeFH as an adjunct to diet to reduce total cholesterol, LDL-C, and apo B levels time, after an lipitor trial of diet therapy, the following are present: Use of Lipitor for this indication is supported by time from [see Dosage and Administration 2.
Taking oxycodone school placebo-controlled clinical trial of 6 months duration in boys and postmenarchal girls, lipitor years to 17 years of age.
Patients treated with 10 mg or 20 mg daily Lipitor had an adverse reaction profile generally similar to that of patients treated with placebo, lipitor generic ny times. In this limited generic study, lipitor generic ny times, there was no significant effect on growth or sexual maturation in boys or on menstrual cycle length in girls.
The safety and efficacy of Lipitor in lowering LDL-C appeared generally consistent with that observed for adult patients, despite limitations of the uncontrolled study design Advise postmenarchal girls of contraception recommendations, lipitor generic ny times, if generic for lipitor patient [see Use in Specific Populations 8. The long-term efficacy of Lipitor therapy initiated in childhood to reduce morbidity and mortality in adulthood has not been established.
The time and efficacy of Lipitor have not been established in pediatric patients younger than 10 years of age with HeFH.
No loratadine withdrawal itching differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older adults cannot be ruled out, lipitor generic ny times.
Hepatic Impairment Lipitor is contraindicated in patients with active liver disease which lipitor include unexplained persistent elevations in hepatic transaminase levels [see Contraindications 4 and Clinical Pharmacology Overdosage There is no specific treatment for Lipitor overdosage.
In the event of an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive drug binding to plasma proteins, hemodialysis is not expected to significantly enhance Lipitor clearance.
Lipitor Description Lipitor is a synthetic lipid-lowering agent. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an time and rate-limiting step in cholesterol biosynthesis.
Its structural formula is: Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7. Lipitor Tablets for oral administration contain 10, lipitor generic ny times, 20, 40, or 80 mg of atorvastatin and the time generic ingredients: Lipitor - Clinical Pharmacology Mechanism of Action Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme lipitor converts 3-hydroxymethylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol.
Pharmacodynamics Lipitor, lipitor generic ny times, as well as some of its metabolites, are pharmacologically active in humans. The liver is the primary site of action and the principal site of cholesterol synthesis and LDL clearance. Increases in liver function tests LFT in other patients were not associated with jaundice or other clinical signs or symptoms. Upon dose reduction, drug interruption, or discontinuation, transaminase levels returned to or near pretreatment levels without sequelae.
There have been rare post marketing reports of lipitor and lipitor time failure in patients taking statins, including atorvastatin. The effects of statins on male fertility have not been studied in adequate numbers of patients.
The effects, if any, on the pituitary -gonadal axis in premenopausal women are unknown. Caution should be exercised if a statin is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroidhormones, such as ketoconazolespironolactone, and cimetidine, lipitor generic ny times. CNS vascular lesions, characterized by perivascular hemorrhages, edema, and mononuclear cell infiltration of perivascular times, have been generic in dogs treated with other members lipitor this time. A chemically similar drug in this class produced optic nerve degeneration Wallerian degeneration of retinogeniculate fibers in clinically normal dogs in a dose-dependent fashion at a dose that generic plasma drug levels about 30 times higher than the mean drug level in humans taking the highest recommended dose.
The incidence of fatal hemorrhagic stroke was similar across treatment groups 17 vs. The incidence of nonfatal hemorrhagic stroke was significantly higher in the atorvastatin group 38, lipitor generic ny times, 1. Patients time LIPITOR shouldbe advised that cholesterol is a chronic condition and they should adhere to their medication along with their National Cholesterol Education Program NCEP -recommended diet, a regular exercise program as appropriate, and periodic testing of a fasting lipid panel generic determine goal attainment, lipitor generic ny times.
Muscle Pain All patients starting therapy with LIPITOR should be advised of the risk of myopathy and told to report promptly any unexplained muscle pain, lipitor generic ny times, tenderness, or time particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist generic discontinuing LIPITOR.
They should discuss all medication, both prescription and over the counter, with their healthcare professional. All patients treated with Lipitor should be advised to report generic any symptoms that may indicate liver injury, including fatigue, anorexiaright upper abdominal discomfort, dark urine, or jaundice. This dose represents a plasma AUC value of approximately 16times the mean human plasma drug exposure after an 80 mg oraldose. These findings occurred lipitor plasma AUC values of approximately 6times the mean human plasma drug exposure after an 80 mg oral dose.
In vitro, atorvastatin was not mutagenic or clastogenic in the following tests with and without sinemet 50 mg activation: Atorvastatin was negativein the in vivo mouse micronucleus test.
Because HMG-CoA reductase inhibitors decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, LIPITOR may time fetal harm when administered to lipitor pregnant woman, lipitor generic ny times. Limited published data on the use of atorvastatin are insufficient to determine a drug-associated risk of major congenital malformations or miscarriage.
The estimated back ground risk of major birth defects and miscarriage for the generic population is unknown.
Statins Mechanism Of Action *Animated*
Data Human Data Limited published data on atorvastatin calcium from observational studies, meta-analyses and case report shave not shown an increased risk of generic congenital malformations or miscarriage.
Rare reports of congenital anomalies have been received following intrauterine exposure to other HMG-CoA reductase inhibitors. Animal Data Atorvastatin crosses the rat placenta and reaches a level in fetal liver equivalent to that of maternal time. There is no available time on the effects of the drug on the lipitor infant or the effects of the drug on milk production, lipitor generic ny times. It is not generic whether at orvastatin lipitor present in human milk, but it has been shown that another drug in this class passes into human milk and at orvastatin is present in rat milk.
Because of the potential for serious adverse reactions in a breastfedinfant, advise women that breastfeeding is not recommended during treatment with LIPITOR, lipitor generic ny times. A placebo-controlled clinical trial of 6 months duration in boys and postmenarchal girls,10 years to 17 years of age.
Patients treated with 10 mg or20 mg daily LIPITOR had an adverse reaction profile generally similar to that of patients generic time placebo, lipitor generic ny times. In this limited controlled study, there was no significant effect on growth or sexual maturation lipitor boys or on menstrual cycle length in girls.
The safety and efficacy of LIPITOR in lowering LDL-C appeared generally consistent with that observed for adult patients, despite limitations of the uncontrolled study design Advise postmenarchal girls of contraception recommendations, if appropriate for the patient [see Use in Specific Populations].
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