Osteoarthritis is a disease of the joints. It results from the gradual breakdown of cartilage that cushions the ends of the bones. This causes swelling inflammation , pain, tenderness, stiffness and disability.
Arcoxia works equally well in older and younger adult patients. If you are over 65 years of age, your doctor will want to appropriately keep a check on you.
No dosage adjustment is necessary for patients over 65 years of age. Children and adolescents Do not give this medicine to children and adolescents under 16 years of age. Other medicines and Arcoxia Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. In particular if you are taking any of the following medicines, your doctor may want to monitor you to check that your medicines are working properly, once you start taking Arcoxia: Arcoxia can be taken with low-dose aspirin.
Arcoxia is not addictive. Do not take Arcoxia if: If you take this medicine after the expiry date has passed, it may not work. You have had heart failure, a heart attack, bypass surgery, chest pain angina , narrow or blocked arteries of the extremities peripheral arterial disease , a stroke or mini stroke TIA or transient ischaemic attack. You have high blood pressure that is not well controlled on blood pressure medication.
You are having major surgery and have conditions which increase your risk of coronary artery disease or atherosclerosis such as high blood pressure, diabetes, high cholesterol or smoking. You are having major surgery on you heart or arteries. If you are not sure whether you should start taking Arcoxia, talk to your doctor. Arcoxia has not been adequately studied in children. Therefore, Arcoxia should not be given to children.
Arcoxia works equally well in older and younger adult patients. Adverse experiences may occur at a higher incidence in older patients compared to younger patients. If you are elderly ie over 65 years of age , your doctor will want to appropriately keep a check on you. No dosage adjustment is necessary for older patients. Before you start to taking Arcoxia tell your doctor if: Arcoxia is not recommended for use during late pregnancy.
If there is a need to consider using Arcoxia during your pregnancy, your doctor will discuss with you the benefits and risks of using it. It is not known if Arcoxia passes into breast milk. You and your doctor should discuss whether you should stop breast-feeding or not take Arcoxia. If you have not told your doctor about any of the above, tell them before you take any Arcoxia.
Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop. Some medicines and Arcoxia may interfere with each other. Renal effects Renal prostaglandins may play a compensatory role in the maintenance of renal perfusion.
Therefore, under conditions of compromised renal perfusion, administration of etoricoxib may cause a reduction in prostaglandin formation and, secondarily, in renal blood flow, and thereby impair renal function. Patients at greatest risk of this response are those with pre-existing significantly impaired renal function, uncompensated heart failure, or cirrhosis.
Monitoring of renal function in such patients should be considered. Fluid retention, oedema and hypertension As with other medicinal products known to inhibit prostaglandin synthesis, fluid retention, oedema and hypertension have been observed in patients taking etoricoxib. For information regarding a dose related response for etoricoxib see section 5. Caution should be exercised in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension and in patients with pre-existing oedema from any other reason.
If there is clinical evidence of deterioration in the condition of these patients, appropriate measures including discontinuation of etoricoxib should be taken. Etoricoxib may be associated with more frequent and severe hypertension than some other NSAIDs and selective COX-2 inhibitors, particularly at high doses.
Therefore, hypertension should be controlled before treatment with etoricoxib see section 4. Blood pressure should be monitored within two weeks after initiation of treatment and periodically thereafter. If blood pressure rises significantly, alternative treatment should be considered.
If signs of hepatic insufficiency occur, or if persistently abnormal liver function tests three times the upper limit of normal are detected, etoricoxib should be discontinued. General If during treatment, patients deteriorate in any of the organ system functions described above, appropriate measures should be taken and discontinuation of etoricoxib therapy should be considered. Medically appropriate supervision should be maintained when using etoricoxib in the elderly and in patients with renal, hepatic, or cardiac dysfunction.
Caution should be used when initiating treatment with etoricoxib in patients with dehydration. It is advisable to rehydrate patients prior to starting therapy with etoricoxib. Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs and some selective COX-2 inhibitors during post-marketing surveillance see section 4. Patients appear to be at highest risk for these reactions early in the course of therapy with the onset of the reaction occurring in the majority of cases within the first month of treatment.
Serious hypersensitivity reactions such as anaphylaxis and angioedema have been reported in patients receiving etoricoxib see section 4. Some selective COX-2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy. Etoricoxib should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. If you buy any medicines, check with a pharmacist that they are suitable for you to take.
This is because you should not take etoricoxib with any other anti-inflammatory painkiller, some of which are available in cold and flu remedies which can be bought 'over the counter'.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking. Can etoricoxib cause problems? Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with etoricoxib.
The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome. Common etoricoxib side-effects What can I do if I experience this?
Indigestion, stomach upset, tummy abdominal pain Stick to simple meals - avoid fatty or spicy foods. If the discomfort continues, speak with your doctor Feeling dizzy or tired Do not drive and do not use tools or machines while affected Constipation or diarrhoea Drink plenty of water Swollen ankles, fluid retention, being aware of your heart beating palpitations , feeling short of breath, bruising, headache and flu-like symptoms If any of these become troublesome, speak with your doctor High blood pressure, changes to some blood tests Your doctor will check for these Important: If you have any breathing difficulties such as wheeze or breathlessness.
If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash. Adverse experiences may occur at a higher incidence in older patients compared to younger patients. If you are elderly i. No dosage adjustment is necessary for older patients. If you have kidney, liver or heart disease, your doctor will want to keep a regular check on you. Your doctor will want to discuss your treatment from time to time.
This is because the risk of heart attacks and strokes might increase after prolonged treatment, especially with high doses. ARCOXIA can increase blood pressure in some people, especially in high doses, and this could increase the risk of heart attacks and strokes. Your doctor will want to check your blood pressure from time to time, to make sure that it is safe to continue treatment. The effect of ARCOXIA on the ability to drive a car or operate machinery has not been studied, although it is thought to be unlikely to have any effect on these activities.
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