Bula do allegra 120mg

Radiolabeled tissue distribution studies in rats indicated that fexofenadine does not cross the blood-brain barrier.

Pseudoephedrine hydrochloride is an orally active sympathomimetic amine and exerts a decongestant action on the nasal mucosa. Pseudoephedrine hydrochloride is recognized as an effective agent for the relief of nasal congestion due to allergic rhinitis. Pseudoephedrine produces peripheral effects similar to those of ephedrine and central effects similar to, but less intense than, amphetamines. It has the potential for excitatory side effects.

At the recommended oral dose, it has little or no pressor effect in normotensive adults. Pharmacokinetics The pharmacokinetics of fexofenadine hydrochloride in subjects with seasonal allergic rhinitis were similar to those in healthy volunteers. Absorption The pharmacokinetics of fexofenadine hydrochloride and pseudoephedrine hydrochloride when administered separately have been well characterized.

Fexofenadine pharmacokinetics were linear for oral doses of fexofenadine hydrochloride up to a total daily dose of mg mg twice daily. Peak fexofenadine plasma concentrations were similar between adolescent years of age and adult subjects.

Coadministration of fexofenadine and pseudoephedrine does not significantly affect the bioavailability of either component. The rate or extent of pseudoephedrine absorption was not affected by food. The protein binding of pseudoephedrine in humans is not known.

Pseudoephedrine hydrochloride is extensively distributed into extravascular sites apparent volume of distribution between 2. Elimination The mean elimination half-life of fexofenadine was Because the absolute bioavailability of fexofenadine hydrochloride has not been established, it is unknown if the fecal component is primarily unabsorbed drug or the result of biliary excretion.

Pseudoephedrine has been shown to have a mean elimination half-life of hours which is dependent on urine pH. The elimination half-life is decreased at urine pH lower than 6 and may be increased at urine pH higher than 8. Special Populations Pharmacokinetics in special populations for renal, hepatic impairment, and age , obtained after a single dose of 80 mg fexofenadine hydrochloride, were compared to those from healthy subjects in a separate study of similar design.

Mean fexofenadine elimination half-lives were similar to those observed in younger subjects. No data are available on the pharmacokinetics of pseudoephedrine in renally-impaired subjects. A decrease in renal function is, therefore, likely to decrease the clearance of pseudoephedrine significantly, thus prolonging the half-life and resulting in accumulation. The pharmacokinetics of fexofenadine hydrochloride in subjects with hepatic disease did not differ substantially from that observed in healthy volunteers.

The effect on pseudoephedrine pharmacokinetics is unknown. Across several trials, no clinically significant gender-related differences were observed in the pharmacokinetics of fexofenadine hydrochloride. Pharmacodynamics Wheal and Flare. Human histamine skin wheal and flare studies following single and twice daily doses of 20 mg and 40 mg fexofenadine hydrochloride demonstrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at hours, and an effect is still seen at 12 hours.

There was no evidence of tolerance to these effects after 28 days of dosing. This concentration was at least 21 times the therapeutic plasma concentration in man based on a 60 mg twice daily fexofenadine hydrochloride dose.

No statistically significant increase in mean QTc interval compared to placebo was observed in subjects with seasonal allergic rhinitis given fexofenadine hydrochloride capsules in doses of 60 mg to mg twice daily for 2 weeks or in 40 healthy volunteers given fexofenadine hydrochloride as an oral solution at doses up to mg twice daily for 6 days. Statistically significant reductions in symptom scores were observed following the first 60 mg dose, with the effect maintained throughout the hour interval.

In general, there was no additional reduction in total symptom scores with higher doses of fexofenadine hydrochloride up to mg twice daily. Although the number of subjects in some of the subgroups was small, there were no significant differences in the effect of fexofenadine hydrochloride across subgroups of subjects defined by gender, age, and race. Onset of action for reduction in total symptom scores, excluding nasal congestion, was observed at 60 minutes compared to placebo following a single 60 mg fexofenadine hydrochloride dose administered to subjects with seasonal allergic rhinitis who were exposed to ragweed pollen in an environmental exposure unit.

Do not exceed the recommended dose. If nervousness, dizziness, or sleeplessness occur, discontinue use and consult the doctor. The product should not be used by patients who are hypersensitive to it or to any of its ingredients. Due to its pseudoephedrine component, this product should not be used by patients with narrow-angle glaucoma, urinary retention, or by patients receiving a monoamine oxidase MAO inhibitor or within 14 days of stopping use of MAO inhibitor. It also should not be used by patients with severe hypertension or severe coronary artery disease.

Patients should be told that this product should be used in pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or nursing infant. Patients should be advised to take the tablet on an empty stomach with water. CLICK HERE Generico do allegra mg Allegra tablets mg contain fexofenadine mg, which is an antihistamine that blocks the action of histamine in allergic reactions, and they are used to treat symptoms of allergic rhinitis runny itchy nose and sneezing and urticaria or hives red itchy limps on the skin.

Aciclovir compresse prezzo. Ever since the nominees for the Oscar Awards were announced. Buy Allegra mg Tablet - strip of 10 tablets at online at 1mg. Allegra fexofenadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Allegra mg E Allegra refers to the mg dose of fexofenadine generic name for Allegra medication. Allegra comes in tablet form and must be ingested orally.

How do I Use Allegra mg? You should take Allegra orally once a day with or without food. Allegra MG Tablet is used in the treatment of symptoms of seasonal allergy like itchy throat, itchy eyes, sneezing or runny nose. Do not overdose if you have missed a dose. Allegra MG Tablet can result in dizziness if consumed with alcohol. Allergies such as runny nose, watery eyes, sneezing, skin itching and hives can be effectively treated with this medicine.

Provides 24 hours of relief from indoor and outdoor allergy symptoms. Used to temporarily relieve runny nose, itchy, wa — — — Generico Remedio Allegra D. Manufactured by Aventis Pharma Inc.

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