Driving and using machines Side effects such as dizziness, vertigo, tiredness and visual disturbances sometimes occur in patients taking Lansoprazole. If you experience side effects like these you should take caution as your ability to react may be decreased.
You alone are responsible to decide if you are in a fit condition to drive a motor vehicle or perform other tasks that demand increased concentration. Because of their effects or undesirable effects, one of the factors that can reduce your ability to do these things safely is your use of medicines.
Descriptions of these effects can be found in other sections. Read all the information in this leaflet for guidance. Discuss with your doctor, nurse or pharmacist if you are unsure about anything. Lansoprazole Capsules contains sucrose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
How to take Lansoprazole Capsules Swallow the capsule whole with a glass of water. If you find the capsules difficult to swallow your doctor may advise on alternative ways to take your medicine. Do not crush or chew these capsules or the content of an emptied capsule because this will stop them from working properly.
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. If you are taking Lansoprazole once a day, try to take it at the same time each day.
You may get best results if you take Lansoprazole first thing in the morning. If you are taking Lansoprazole twice a day, you should have the first dose in the morning and the second dose in the evening.
The dose of Lansoprazole depends on your condition. The recommended dose of Lansoprazole is given below. Your doctor will sometimes prescribe you a different dose and will tell you how long your treatment will last. Treatment of heartburn and acid regurgitation: If symptoms persist you should report to your doctor. There is no significant food effect if lansoprazole is given before meals. Plasma protein binding is constant over the concentration range of 0. Lansoprazole is extensively metabolized in the liver.
Two metabolites have been identified in measurable quantities in plasma the hydroxylated sulfinyl and sulfone derivatives of lansoprazole. These metabolites have very little or no antisecretory activity. The two active species are not present in the systemic circulation. The plasma elimination half-life of lansoprazole is less than two hours while the acid inhibitory effect lasts more than 24 hours.
Therefore, the plasma elimination half-life of lansoprazole does not reflect its duration of suppression of gastric acid secretion. Following single-dose oral administration of lansoprazole delayed-release capsules, virtually no unchanged lansoprazole was excreted in the urine. In one study, after a single oral dose of 14C-lansoprazole, approximately one-third of the administered radiation was excreted in the urine and two-thirds was recovered in the feces.
This implies a significant biliary excretion of the lansoprazole metabolites. Specific Populations Pediatric Use: One to 17 years of age The pharmacokinetics of lansoprazole were studied in pediatric patients with GERD aged one to 11 years and 12 to 17 years in two separate clinical studies.
Mean Cmax and AUC values observed on Day 5 of dosing were similar between the two dose groups and were not affected by weight or age within each weight-adjusted dose group used in the study. In adolescent subjects aged 12 to 17 years, subjects were randomized to receive lansoprazole at 15 mg or 30 mg daily. Mean Cmax and AUC values of lansoprazole were not affected by body weight or age; and nearly dose-proportional increases in mean Cmax and AUC values were observed between the two dose groups in the study.
Overall, lansoprazole pharmacokinetics in pediatric patients aged 1 to 17 years were similar to those observed in healthy adult subjects. Neonate to less than one year of age Refer to Section 8. Because the mean half-life in the elderly remains between 1. Peak plasma levels were not increased in the elderly. No dosage adjustment is necessary in the elderly [see Use in Specific Populations 8.
In patients with severe renal impairment, plasma protein binding decreased by 1. Patients with renal impairment had a shortened elimination half-life and decreased total AUC free and bound. The AUC for free lansoprazole in plasma, however, was not related to the degree of renal impairment; and the Cmax and Tmax time to reach the maximum concentration were not different than the Cmax and Tmax from subjects with normal renal function.
Intravenous lansoprazole is approved for patients who are unable to take oral lansoprazole. The approved intravenous dose is 30 mg daily for up to 7 days. It is recommended that capsules be taken before meals for maximum effect. Capsules should be swallowed whole and should not be crushed, split or chewed.
For those with difficulty swallowing , the capsule should be opened and the granular contents sprinkled on a tablespoon of apple sauce, ENSURE pudding, cottage cheese, yogurt or strained pears and swallowed immediately. Granules also may be mixed in two ounces 60 ml of apple, orange or tomato juice and swallowed immediately.
For patients with a nasogastic tube, mix the granules can be mixed in two ounces of apple juice and injected through the nasogastric tube. Which drugs or supplements interact with lansoprazole?
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