Precautions Tell the doctor if you cure over 28 days and feel dizziness, weariness, low temperature, irregular heartbeats, problems with breathing, sleepiness, belly pain,problems with eyes, changes in your feelings. Also if you cure with SSRIs antidepressants, you may feel somnolence, euphoria, giddiness, perspiration, fever.
Don't use the food with high tyramine content. Avoid using the drug if you are pregnant, have an allergy, blood disorders or some chronic infections. Contraindications Don't use the medicine if you have an allergic reaction to the components. To help you remember, take Linezolid mg at the same time s every day. Continue to take Linezolid mg until the full prescribed amount is finished, even if symptoms disappear after a few days.
Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition lasts or gets worse. Diarrhea, headache, nausea, vomiting, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that your doctor has prescribed Linezolid mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Linezolid mg do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: Linezolid mg may rarely cause a severe intestinal condition Clostridium difficile-associated diarrhea due to a type of resistant bacteria.
This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: Do not use anti-diarrhea or opioid medications if you have any of these symptoms because these products may make them worse. Use of Linezolid mg for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.
The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take. In most of these cases, a history of seizures or risk factors for seizures was reported.
Patients should be advised to inform their physician if they have a history of seizures. Monoamine oxidase inhibitors Linezolid is a reversible, non-selective inhibitor of monoamine oxidase MAOI ; however, at the doses used for antibacterial therapy, it does not exert an anti-depressive effect.
Therefore, linezolid is not recommended for use in these circumstances unless close observation and monitoring of the recipient is possible see sections 4. Use with tyramine-rich foods Patients should be advised against consuming large amounts of tyramine-rich foods see section 4.
Superinfection The effects of linezolid therapy on normal flora have not been evaluated in clinical trials. The use of antibiotics may occasionally result in an overgrowth of non-susceptible organisms.
Should superinfection occur during therapy, appropriate measures should be taken. Special populations Linezolid should be used with special caution in patients with severe renal insufficiency and only when the anticipated benefit is considered to outweigh the theoretical risk see sections 4. It is recommended that linezolid should be given to patients with severe hepatic insufficiency only when the perceived benefit outweighs the theoretical risk see sections 4.
Impairment of fertility Linezolid reversibly decreased fertility and induced abnormal sperm morphology in adult male rats at exposure levels approximately equal to those expected in humans; possible effects of linezolid on the human male reproductive system are not known see section 5. Clinical trials The safety and effectiveness of linezolid when administered for periods longer than 28 days have not been established.
Controlled clinical trials did not include patients with diabetic foot lesions, decubitus or ischaemic lesions, severe burns or gangrene. Therefore, experience in the use of linezolid in the treatment of these conditions is limited. There are very limited data from drug interaction studies and on the safety of linezolid when administered to patients on concomitant medications that might put them at risk from MAO inhibition.
Potential interactions producing elevation of blood pressure In normotensive healthy volunteers, linezolid enhanced the increases in blood pressure caused by pseudoephedrine and phenylpropanolamine hydrochloride. Co-administration of linezolid with either pseudoephedrine or phenylpropanolamine resulted in mean increases in systolic blood pressure of the order of mmHg, compared with mmHg increases with linezolid alone, mmHg with either pseudoephedrine or phenylpropanolamine alone and mmHg with placebo.
Similar studies in hypertensive subjects have not been conducted. It is recommended that doses of drugs with a vasopressive action, including dopaminergic agents, should be carefully titrated to achieve the desired response when co-administered with linezolid.
What are the side effects of Linezolid? Like other medicines, Linezolid can cause some side effects. If they do occur, the side effects of Linezolid are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately. It is pertinent to note that side effects of Linezolid cannot be anticipated.
Storage Store your medicines at room temperature between C F. Note The information presented at the site has a general character.
Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes.
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