Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If the dose of Lovastatin is changed, the same procedure should be repeated. Lovastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants.
Propranolol In normal volunteers, there was no clinically significant pharmacokinetic or pharmacodynamic interaction with concomitant administration of single doses of Lovastatin and propranolol. Digoxin In patients with hypercholesterolemia, concomitant administration of Lovastatin and digoxin resulted in no effect on digoxin plasma concentrations.
Results of clinical trials with drugs in this class have been inconsistent with regard to drug effects on basal and reserve steroid levels. However, clinical studies have shown that Lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration.
In the same study, the mean testosterone response to HCG was slightly but not significantly reduced after treatment with Lovastatin 40 mg daily for 16 weeks in 21 men. The effects of HMG-CoA reductase inhibitors on male fertility have not been studied in adequate numbers of male patients. The effects, if any, on the pituitary-gonadal axis in premenopausal women are unknown. Patients treated with Lovastatin who develop clinical evidence of endocrine dysfunction should be evaluated appropriately.
Caution should also be exercised if an HMG-CoA reductase inhibitor or other agent used to lower cholesterol levels is administered to patients also receiving other drugs e. An increased incidence of thyroid neoplasms in rats appears to be a response that has been seen with other HMG-CoA reductase inhibitors. Liver carcinomas were significantly increased in high dose females and mid- and high dose males, with a maximum incidence of 90 percent in males.
The incidence of adenomas of the liver was significantly increased in mid- and high dose females. Drug treatment also significantly increased the incidence of lung adenomas in mid- and high dose males and females. Adenomas of the Harderian gland a gland of the eye of rodents were significantly higher in high dose mice than in controls. No evidence of mutagenicity was observed in a microbial mutagen test using mutant strains of Salmonella typhimurium with or without rat or mouse liver metabolic activation.
In addition, no evidence of damage to genetic material was noted in an in vitro alkaline elution assay using rat or mouse hepatocytes, a V mammalian cell forward mutation study, an in vitro chromosome aberration study in CHO cells, or an in vivo chromosomal aberration assay in mouse bone marrow.
Similar findings were seen with another drug in this class. No drug-related effects on fertility were found in studies with lovastatin in rats. No microscopic changes were observed in the testes from rats of either study. The clinical significance of these findings is unclear. Safety in pregnant women has not been established. No effect was seen in male rats. Grundy SM "Can statins cause chronic low-grade myopathy? Gonyeau MJ "Statins and osteoporosis: Ahmand S "Lovastatin-induced myopathy in a hypothyroid patient.
Ahmad S "Lovastatin and peripheral neuropathy. Tobert JA "Lovastatin-associated sleep and mood disturbances. Vonpohle WR "Recurrent hyperthermia due to lovastatin. Ahmad S "Lovastatin-induced lupus erythematosus. Assessment of the human lens after 48 weeks of treatment with lovastatin.
Gregoor PJ "Atorvastatin may cause nightmares. A meta-analysis of large randomized clinical trials. Some side effects may not be reported. You may report them to the FDA. Could this be caused by lovastatin, and how will my doctor determine if this is the case?
Most medications are filtered out of the body through the liver, the kidney, or both, and in the case of Mevacor the generic name is lovastatin , and all statins, the liver is involved. A liver function test LFT is recommended before starting a statin if there is a history of liver disease.
Then, after starting Mevacor losvastatin , an LFT should be taken before 40mg is started. It is recommended to check cholesterol levels at six weeks, at which time the LFT can be measured as well.
Then, periodic tests should be taken until levels go back to normal. If they increase to three times the normal upper limit normal: Patti Brown, PharmD Q: Can 10 mg of lovastatin cause headaches? Lovastatin is a cholesterol-lowering medication that belongs to a class of drugs called "statins. Lovastatin reduces low-density lipoprotein LDL cholesterol and total cholesterol in the blood.
This can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease. Common side effects of lovastatin include mild stomach pain, gas, bloating, stomach upset, heartburn, nausea, constipation, and diarrhea. This is not a complete list of side effects that can occur with lovastatin. Your doctor or healthcare provider is best able to properly evaluate your medical condition and give recommendations based on your specific circumstances.
Consult your doctor if headaches are severe, persistent, or bothersome. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications. Sarah Lewis, RPh Q: Can lovastatin cause pain in the buttocks? Mevacor lovastatin lowers cholesterol by blocking the production of cholesterol in the body. Lowering cholesterol can help prevent heart disease and hardening of the arteries, which can lead to heart attack and stroke.
According to the FDA approved drug information, in rare cases, lovastatin can cause the breakdown of skeletal muscle tissue.
Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. This condition can result in kidney failure. Lovastatin can interact with other medications, when your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, as well as the foods you eat.
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