According to multiple studies conducted, in thousands of patients taking Mobic, the most commonly encountered side effects involved the gastrointestinal system abdominal pain, diarrhea, nausea, and upset stomach , headache, and flu-like symptoms sore throat, cough, runny nose. More serious and rare side effects can occur, including fever, rash, hives, itching, swelling, or difficulty breathing or swallowing.
If you experience any of the more serious side effects associated with meloxicam, the physician should be contacted immediately. However, meloxicam should be used with caution in patients who are also taking Plavix clopidogrel , as it has been shown in studies to cause gastrointestinal bleeding in some patients.
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Liver function should be monitored regularly during long-term treatment. If used for the short-term treatment of pain or fever, diclofenac has not been found more hepatotoxic than other NSAIDs. As of December , Endo, Novartis, and the US FDA notified healthcare professionals to add new warnings and precautions about the potential for elevation in liver function tests during treatment with all products containing diclofenac sodium.
Postmarketing surveillance has reported cases of severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver transplantation. Physicians should measure transaminases periodically in patients receiving long-term therapy with diclofenac.
Based on clinical trial data and postmarketing experiences, transaminases should be monitored within 4 to 8 week after initiating treatment with diclofenac. Renal[ edit ] NSAIDs "are associated with adverse renal [kidney] effects caused by the reduction in synthesis of renal prostaglandins " [22] in sensitive persons or animal species, and potentially during long-term use in nonsensitive persons if resistance to side effects decreases with age.
Consequently, the same precautions regarding renal risk that are followed for nonselective NSAIDs should be used when selective COX-2 inhibitors are administered. Studies in Pakistan showed diclofenac caused acute kidney failure in vultures when they ate the carcasses of animals that had recently been treated with it. Drug-sensitive species and individual humans are initially assumed to lack genes expressing specific drug detoxification enzymes.
These symptoms are rare, but exist in significant enough numbers to include as potential side effects. These include depression, anxiety, irritability, nightmares, and psychotic reactions. It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Whether To Use Some people refuse to use meloxicam for any of their cats, healthy or otherwise, preferring to rely on other medications, usually painkillers. I do not personally view meloxicam as a last resort treatment.
Yes, there are other treatments available for pain control in cats, but meloxicam is anti-inflammatory, whereas most of the alternatives are simply painkillers. Meloxicam is also usually easy to give, very effective and reasonably priced.
I would definitely consider using meloxicam for a cat whose kidneys appeared fine in tests and who would benefit from it, such as my arthritic Karma.
In fact, I wish I had started Karma on it far sooner than I did. Buying into the fear of using NSAIDs in cats, I did not start giving Karma meloxicam until she was already sixteen years old and had had arthritis for some years.
I am still kicking myself for not giving it to her sooner, because the difference was like night and day: We also used meloxicam for Harpsie when his arthritis flared up acutely following a fall off a sofa while we were out and he was in dreadful pain which other medications did not seem to help he was literally screaming. It worked very well and caused no long term problems for him, but since Harpsie had PKD , we only used it at a very low dose, and much less frequently than normally recommended, and it still controlled the pain effectively.
We checked his kidney values a month later they were fine. If either of them had had CKD, I would still have considered using it at very carefully dosed levels with regular monitoring , bearing in mind that controlling pain is more important for quality of life than anything else. It may be better for me to keep my cats around for as long as possible, but I am not convinced that it is better for my cats to live a longer but pain-filled life. Meloxicam Interactions Close monitoring is required if NSAIDs are used in cats taking ACE inhibitors such as benazepril or enalapril or diuretics because using these treatments together increases the risk of kidney problems.
Do not use meloxicam at the same time as corticosteroids. This is extremely rare. Dealing with Adverse Reactions Most cats who develop kidney problems after using meloxicam are suffering from acute kidney injury AKI. Therefore their kidney values in blood tests may be extremely high, with creatinine often in the high teens. A treatment programme which includes days of IV fluid therapy hospitalisation , followed by weeks of sub-Q fluids at home, is often recommended by the manufacturers, but talk to them see below and see what they suggest for your cat.
I would also suggest that you ask the manufacturers to pay your veterinary costs - I know they have done this for some people, although they have not necessarily paid the full costs. It would appear that they may pay more if your vet calls. Do not give up hope!
Acute kidney injury is difficult to treat, but not impossible: Reporting Adverse Reactions If you believe your cat has developed kidney disease as a result of using meloxicam, you should report this as follows: Apparently the manufacturers are not obliged to report any cases of kidney problems to the FDA because renal failure is already listed in the package insert as a possible side effect, but I believe it is very important for the FDA to be fully aware of the scale of the problem.
The manufacturer's contact number is , though they will only speak to vets. You should also report it to the Veterinary Drugs Directorate. You should report it to the Veterinary Medicines Directorate. There is interest in using meloxicam for reasons other than pain control, as follows:
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