The oral granules may either be swallowed whole, or dissolved in 1 teaspoonful 5 mL of cold or room temperature baby formula or breast milk, or mixed with a spoonful of soft food, such as applesauce, carrots, rice, or ice cream. The oral granules should not be chewed. Do not mix this medicine with any other liquid other than baby formula or breast milk.
The mixed medicine must be given within 15 minutes and must not be stored for future use. Dosing TOP The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.
The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For treatment and prevention of asthma: For oral dosage form tablets: Adults and teenagers 15 years of age and older—10 milligrams mg once a day in the evening.
Children and teenagers younger than 15 years of age—Use and dose must be determined by your doctor. For oral dosage form chewable tablets: Children and teenagers 6 to 14 years of age—5 milligrams mg once a day in the evening. Children 2 to 5 years of age—4 mg once a day in the evening. Children younger than 2 years of age—Use and dose must be determined by your doctor.
For oral dosage form granules: Children 2 to 5 years of age—4 milligrams mg one packet once a day in the evening. What you need to know before you take Montelukast Paediatric 3. How to take Montelukast Paediatric 4. Possible side effects 5. How to store Montelukast Paediatric 6. Contents of the pack and other information 1. Leukotrienes cause narrowing and swelling of airways in the lungs. By blocking leukotrienes, Montelukast Paediatric improves asthma symptoms and helps control asthma.
When Montelukast Paediatric should be used Your doctor has prescribed Montelukast Paediatric to treat asthma, preventing your asthma symptoms during the day and night. Your doctor will determine how Montelukast Paediatric should be used depending on the symptoms and severity of your or your child's asthma. Asthma is a long-term disease. This narrowing of airways worsens and improves in response to various conditions. Symptoms of asthma include: Coughing, wheezing, and chest tightness.
Talk to your doctor or pharmacist before you or your child take Montelukast Paediatric. If an attack occurs, follow the instructions your doctor has given you or your child. Always have your inhaled rescue medicine for asthma attacks with you. Montelukast Paediatric should not be used instead of other asthma medications your doctor has prescribed for you or your child.
Children and adolescents Do not give this medicine to children less than 6 years of age. There are different form s of this medicine available for paediatric patients under 18 years of age based on age range. Other medicines and Montelukast Paediatric Tell your doctor or pharmacist if you or your child are taking or have recently taken or might take any other medicines including those obtained without a prescription.
Some medicines may affect how Montelukast Paediatric works, or Montelukast Paediatric may affect how other medicines work. Tell your doctor if you or your child is taking the following medicines before starting Montelukast Paediatric: Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Montelukast Paediatric.
Pregnancy Your doctor will assess whether you can take Montelukast Paediatric during this time. Breast-feeding It is not known if Montelukast Paediatric appears in breast milk. You should consult your doctor before taking Montelukast Paediatric if you are breast-feeding or intend to breast-feed.
Driving and using machines Montelukast Paediatric is not expected to affect your ability to drive a car or operate machinery. Montelukast, compared with placebo, decreased peripheral blood eosinophils in adult and paediatric patients. In a separate study, treatment with montelukast significantly decreased eosinophils in the airways as measured in sputum.
In adult and paediatric patients 2 to 14 years of age, montelukast, compared with placebo, decreased peripheral blood eosinophils while improving clinical asthma control. Clinical efficacy and safety In studies in adults, montelukast, 10 mg once daily, compared with placebo, demonstrated significant improvements in morning FEV1 Improvement in patient-reported daytime and nighttime asthma symptoms scores was significantly better than placebo. However, compared with beclomethasone, a high percentage of patients treated with montelukast achieved similar clinical responses e.
In an 8-week study in paediatric patients 6 to 14 years of age, montelukast 5 mg once daily, compared with placebo, significantly improved respiratory function FEV1 8.
In a month study comparing the efficacy of montelukast to inhaled fluticasone on asthma control in paediatric patients 6 to 14 years of age with mild persistent asthma, montelukast was non-inferior to fluticasone in increasing the percentage of asthma rescue-free days RFDs , the primary endpoint. Averaged over the month treatment period, the percentage of asthma RFDs increased from The between group difference in LS mean increase in the percentage of asthma RFDs was statistically significant Both montelukast and fluticasone also improved asthma control on secondary variables assessed over the 12 month treatment period: FEV1 increased from 1.
The percentage of patients with an asthma attack an asthma attack being defined as a period of worsening asthma that required treatment with oral steroids, an unscheduled visit to the doctor's office, an emergency room visit, or hospitalisation was The percentage of patients with systemic mainly oral corticosteroid use during the study period was The between group difference in LS means was significant: Sixty percent of patients were not on any other controller therapy.
Montelukast improved daytime symptoms including coughing, wheezing, trouble breathing and activity limitation and nighttime symptoms compared with placebo. Patients receiving montelukast had more days without asthma than those receiving placebo. A treatment effect was achieved after the first dose. The percentage reduction in yearly EE rate was In a placebo-controlled study in paediatric patients 6 months to 5 years of age who had intermittent asthma but did not have persistent asthma, treatment with montelukast was administered over a month period, either as a once-daily 4 mg regimen or as a series of day courses that each were started when an episode of intermittent symptoms began.
No significant difference was observed between patients treated with montelukast 4 mg or placebo in the number of asthma episodes culminating in an asthma attack, defined as an asthma episode requiring utilization of health-care resources such as an unscheduled visit to a doctor's office, emergency room, or hospital; or treatment with oral, intravenous, or intramuscular corticosteroid.
Efficacy of montelukast is supported in paediatric patients 6 months to 2 years of age by extrapolation from the demonstrated efficacy in patients 2 years of age and older with asthma, and is based on similar pharmacokinetic data, as well as the assumption that the disease course, pathophysiology and the medicinal products's effect are substantially similar among these populations.
Significant reduction of exercise-induced bronchoconstriction EIB was demonstrated in a week study in adults maximal fall in FEV1
How to store Montelukast Paediatric 6. Children and teenagers younger than 15 years of age—Use and dose must be determined by your doctor. Do not mix this medicine with any other liquid other than baby formula or breast milk, singulair pediatric price. However, individual responses to medication may vary. You must tell your doctor right away if you get one or more of these symptoms See section 2. Follow your doctor's orders or the directions on the label. However, singulair pediatric price, if you or your child misses a dose, just resume the usual schedule of one chewable tablet once daily. The first two numbers indicate the month; the last four numbers indicate the year. In adult and paediatric patients 2 to 14 years of age, montelukast, compared with singulair, decreased peripheral blood eosinophils while improving clinical asthma control. A treatment effect was achieved after the first dose. Before Using TOP In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. By reporting side effects you can help provide more price on the safety of this medicine. Keep out of the reach of children. Infants 6 months to 23 months of age—4 mg one packet pediatric a day in the evening. This medicine is for oral use. This dose is equivalent to 25, times the recommended daily adult human dose based on an adult patient weight of 50 kg. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking Montelukast Paediatric.
This includes any possible side effects not listed in this leaflet. The percentage reduction in yearly EE rate was This medicine is for oral use. Cytochrome P 2C8 is the major enzyme in the metabolism of montelukast. Children and adolescents Do not give this medicine to children less than 6 years of age. Based on in vitro results in human liver microsomes, therapeutic plasma concentrations of montelukast do not inhibit cytochromes P 3A4, 2C9, 1A2, singulair pediatric price, 2A6, 2C19, or 2D6. If the medicine becomes pediatric or shows any other signs of deterioration, you should seek the advice of your doctor or pharmacist who will tell you what to do, singulair pediatric price. The effect in both prices was demonstrated at the end of the once-daily dosing interval. Children 2 to 5 years of age—4 mg once a day, taken in ampicillin resistance escherichia morning or evening. The 4 mg granule formulation is singulair to the 4 singulair chewable tablet pediatric administered to adults in the fasted price. The steady-state volume of distribution of montelukast averages litres. However, if you or your child misses a dose, just resume the usual schedule of one chewable tablet once daily. Studies in rats with radiolabelled montelukast indicate minimal distribution across the blood-brain barrier.
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