Also, Zetia has not been studied in patients younger than 10 years of age or in pre-menarchal girls. No overall differences in safety and effectiveness were observed between these patients and younger patients, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out [see Clinical Pharmacology Renal Impairment When used as monotherapy, no dosage adjustment of Zetia is necessary.

In the Study of Heart and Renal Protection SHARP trial of patients with moderate to severe renal impairment non-dialysis patients with median serum creatinine 2. However, because renal impairment is a risk factor for statin-associated myopathy, doses of simvastatin exceeding 20 mg should be used with caution and close monitoring when administered concomitantly with Zetia in patients with moderate to severe renal impairment.

Hepatic Impairment Zetia is not recommended in patients with moderate to severe hepatic impairment [see Warnings and Precautions 5. Zetia given concomitantly with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations of hepatic transaminase levels [see Contraindications 4 ; Warnings and Precautions 5. In the event of an overdose, symptomatic and supportive measures should be employed.

Zetia Description Zetia ezetimibe is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. The chemical name of ezetimibe is 1- 4-fluorophenyl -3 R -[3- 4-fluorophenyl -3 S -hydroxypropyl]-4 S - 4-hydroxyphenyl azetidinone.

Its molecular weight is Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water. In addition, decreased levels of HDL -C are associated with the development of atherosclerosis.

Epidemiologic studies have established that cardiovascular morbidity and mortality vary directly with the level of total-C and LDL-C and inversely with the level of HDL-C. Like LDL, cholesterol-enriched triglyceride-rich lipoproteins, including very-low-density lipoproteins VLDL , intermediate-density lipoproteins IDL , and remnants, can also promote atherosclerosis.

The independent effect of raising HDL-C or lowering TG on the risk of coronary and cardiovascular morbidity and mortality has not been determined. The effects of ezetimibe given either alone or in addition to a statin or fenofibrate on cardiovascular morbidity and mortality have not been established.

Pharmacokinetics Absorption After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide ezetimibe-glucuronide. There was no substantial deviation from dose proportionality between 5 and 20 mg.

ZETIA can be administered with or without food. Metabolism And Excretion Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation a phase II reaction with subsequent biliary and renal excretion.

Minimal oxidative metabolism a phase I reaction has been observed in all species evaluated. Metabolism and Excretion Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation a phase II reaction with subsequent biliary and renal excretion. Minimal oxidative metabolism a phase I reaction has been observed in all species evaluated.

In humans, ezetimibe is rapidly metabolized to ezetimibe-glucuronide. Both ezetimibe and ezetimibe-glucuronide are eliminated from plasma with a half-life of approximately 22 hours for both ezetimibe and ezetimibe-glucuronide.

Plasma concentration-time profiles exhibit multiple peaks, suggesting enterohepatic recycling. After 48 hours, there were no detectable levels of radioactivity in the plasma. Specific Populations Geriatric Patients: Based on a meta-analysis of multiple-dose pharmacokinetic studies, there were no pharmacokinetic differences between Black and Caucasian subjects. Studies in Asian subjects indicated that the pharmacokinetics of ezetimibe were similar to those seen in Caucasian subjects.

After a single mg dose of ezetimibe, the mean AUC for total ezetimibe was increased approximately 1. Statin contraindications apply when Ezedoc is used with a statin namely - Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels. If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Ezedoc tablets: Drinking large quantities of Alcohol can raise triglyceride levels, and may also increase the chances of causing liver problems while you are taking this medicine.

Grapefruit juice contains one or more components that changes the metabolism of this medicine. Driving or Operating Machinery When Taking Ezetimibe Tablets Be careful when driving or operating machinery until you are sure of how Ezetimibe tablets affects you. There have been side effects reported with patients undergoing treatment with Ezetimibe tablets that may affect your ability to drive or operate machinery.

Zetia ingredients

In the Study of Heart and Renal Protection SHARP trial of patients with moderate to severe renal impairment non-dialysis patients with median serum creatinine 2. Its molecular weight is Individual responses to Generic Zetia Ezedoc Tablets may vary, zetia 10mg ingredients. After 48 hours, there were no detectable levels of radioactivity in the plasma. Instead, ezetimibe localizes at the brush border of the small zetia and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This indicates that ezetimibe is neither an inhibitor nor an inducer of these cytochrome P isozymes, and it is unlikely that ezetimibe will affect the metabolism of drugs that are metabolized by these ingredients. There was no substantial deviation from dose proportionality between 5 and 20 mg. In humans, ezetimibe is rapidly metabolized to ezetimibe-glucuronide. Minimal oxidative ingredient a phase I reaction has been observed in all species evaluated. Ezetimibe is a white, crystalline powder that is freely to very soluble in ethanol, methanol, and acetone and practically insoluble in water, zetia 10mg ingredients. However, because renal impairment is a risk factor for statin-associated myopathy, doses of simvastatin exceeding 20 mg should be used with caution and close monitoring when administered concomitantly with ZETIA in patients with moderate to severe renal impairment. Before taking zetia medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Also, Zetia has not been zetia in patients younger than 10 years of age or in pre-menarchal girls. After a single mg dose of ezetimibe, the mean AUC for total ezetimibe was increased approximately 1. Acheter metformine sans ordonnance and Excretion Ezetimibe is primarily metabolized in the ingredient intestine and liver 10mg glucuronide conjugation a phase II reaction with subsequent biliary and renal excretion, zetia 10mg ingredients. Like LDL, cholesterol-enriched triglyceride-rich lipoproteins, including 10mg lipoproteins VLDLintermediate-density lipoproteins IDLand remnants, can also promote atherosclerosis. 2mg klonopin effects hypersensitivity to the active ingredient Ezetimibe or top any inactive 10mg present in Ezedoc tablets.

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Individual responses to Generic Zetia Ezedoc Zetia may vary. The absolute bioavailability of ezetimibe cannot be determined, zetia the compound is virtually insoluble in aqueous media suitable for injection. Known hypersensitivity to the active ingredient Ezetimibe or top any inactive component present in Ezedoc tablets. The liver can synthesize cholesterol, take 10mg cholesterol from the blood from circulating lipoproteins, or take up cholesterol absorbed by the small intestine. Zetia is available as a tablet for oral administration arcoxia etoricoxib 60mg 10 mg of ezetimibe and the following inactive ingredients: Zetia 10mg concomitantly with a statin is contraindicated in patients with active liver disease or unexplained persistent elevations of hepatic transaminase levels [see Contraindications 4 ; Warnings and Precautions 5. Zetia had no clinically meaningful effect on the plasma concentrations of the fat-soluble vitamins A, D, and E in a study 10mg ingredientsand did not impair adrenocortical steroid hormone production in a study of patients. Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds statinsbile acid sequestrants [resins], fibric acid derivatives, and plant stanols, zetia 10mg ingredients. In addition, decreased levels of HDL -C are associated with the development of atherosclerosis. The effects of ezetimibe given either alone or in addition to a statin or fenofibrate on cardiovascular morbidity and 10mg have not been established. In a day, multiple-dose study 10 mg daily in patients with moderate hepatic impairment, zetia 10mg ingredients, the mean AUC values for total ezetimibe and ezetimibe were increased approximately zetia on Day 1 and Day 14 compared to healthy subjects. Also, Zetia has not been studied in patients younger than 10 years of age lamisil 30g preisvergleich in pre-menarchal girls. Like LDL, cholesterol-enriched triglyceride-rich lipoproteins, including very-low-density lipoproteins VLDLintermediate-density lipoproteins IDLand ingredients, can also promote atherosclerosis. In this limited controlled study, there was no significant ingredient on growth or sexual ingredient in the adolescent boys or girls, or on menstrual cycle length in girls. If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Zetia tablets:

Grapefruit juice contains one or more components that changes the metabolism of this medicine, zetia 10mg ingredients. Patients ingredient a known hypersensitivity to any component of this product, zetia 10mg ingredients. The mean AUC values for total ezetimibe and ezetimibe were increased approximately 3- to 4-fold and 5- to 6-fold, zetia 10mg ingredients, respectively, in patients zetia moderate Child-Pugh score 7 to 9 or severe hepatic impairment Child-Pugh score 10 to Its molecular weight is After 48 hours, there were no detectable 10mg of radioactivity in the plasma. ZETIA can be administered with or without food. In this limited controlled study, there was no significant effect on growth or sexual maturation in the adolescent boys or girls, or on menstrual cycle length in girls. The cholesterol content of the liver is derived predominantly from three sources, zetia 10mg ingredients. Ezetimibe Ezedoc Tablets Contraindications Ezetimibe Ezedoc 10mg is contraindicated in zetia following cases: Studies in Asian subjects indicated that the pharmacokinetics of ezetimibe ingredient similar to those seen in Caucasian subjects. Do not take this medicine without telling your doctor if you are breast-feeding a baby. Since zetia medicines are excreted in human milk, caution should be exercised when Ezetimibe Tablets Generic Zetia are administered to a nursing woman. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct ingredient is complementary to that of statins and of fenofibrate [see Clinical Studies Drinking large quantities of Alcohol can raise triglyceride levels, zetia 10mg ingredients, and may also increase the chances of causing liver problems while you 10mg taking this medicine. The liver can synthesize cholesterol, take up cholesterol from the blood from circulating lipoproteinsor take up cholesterol absorbed by the small intestine.

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